|
Atrial Fibrillation
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated the association between polymorphism in angiotensinogen (AGT) and angiotensin-converting enzyme gene and risk of acquired AF in a pair-matched case-control study conducted in Chinese Hans.
|
19932491 |
2010 |
|
Atrial Fibrillation
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We identified 21 SNPs and the angiotensin-converting enzyme insertion/deletion polymorphism that were reported to be associated with AF in the literature.
|
21056700 |
2011 |
|
Atrial Fibrillation
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We genotyped the insertion/ deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene in 138 HCM patients (26 with AF, 112 with sinus rhythm).
|
12166654 |
2002 |
|
Atrial Fibrillation
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study suggests that the presence of the D allele in hypertensive patients with AF is associated with attenuation of type-I collagen degradation, and that therapy with ACE inhibitors increases degradation of collagen type I.
|
17927479 |
2007 |
|
Atrial Fibrillation
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study demonstrates the association of RAS gene polymorphisms with nonfamilial structural AF and may provide the rationale for clinical trials to investigate the use of ACE inhibitor or angiotensin II antagonist in the treatment of structural AF.
|
15023884 |
2004 |
|
Atrial Fibrillation
|
0.400 |
Biomarker
|
disease |
BEFREE |
This article reviews clinical trials on the use of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) for the prevention of AF.
|
20636314 |
2010 |
|
Atrial Fibrillation
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The T allele carriers (TT + CT) had significantly increased risk of AF compared with the CC homozygotes (OR 1.94, 95% CI 1.20-3.14; adjusted P=0.006) in a logistic regression model after controlling age, left atrial dimension, and the use of angiotensin-converting enzyme inhibitors and/or angiotensin receptor blockers.
|
19665460 |
2009 |
|
Atrial Fibrillation
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The results suggested an association between ACE insertion/deletion and AF risk.
|
20826259 |
2010 |
|
Atrial Fibrillation
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
The purpose of this study was to investigate whether response to antiarrhythmic drug (AAD) therapy in patients with AF is modulated by the ACE I/D polymorphism.
|
17556195 |
2007 |
|
Atrial Fibrillation
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate the role of the ACE I/D polymorphism in relation to the different clinical forms of AF, lone and secondary nonvalvular atrial fibrillation (NVAF).
|
17113662 |
2007 |
|
Atrial Fibrillation
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to investigate the association of the angiotensin-converting enzyme 2350 G/A polymorphism with atrial fibrillation in Han Chinese patients with essential hypertension.
|
24270955 |
2013 |
|
Atrial Fibrillation
|
0.400 |
Biomarker
|
disease |
BEFREE |
Significant differences in the local conformations and kinetic properties of heart and lung ACEs demonstrate tissue specificity of ACE and provide a structural base for the development of mAbs able to distinguish heart and lung ACEs as a potential blood test for predicting atrial fibrillation risk.
|
28771512 |
2017 |
|
Atrial Fibrillation
|
0.400 |
Biomarker
|
disease |
BEFREE |
Renin-angiotensin system (RAS) inhibition via angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers may reduce the risk of developing atrial fibrillation (AF) in certain populations, but the evidence is conflicting.
|
27179719 |
2016 |
|
Atrial Fibrillation
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of the angiotensin-converting enzyme and angiotensinogen gene in patients with atrial fibrillation.
|
21436211 |
2011 |
|
Atrial Fibrillation
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests that ACE I/D polymorphism is associated with AF and the DD genotype may be an independent predictive factor for AF in patients with hypertensive heart disease.
|
19117407 |
2009 |
|
Atrial Fibrillation
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Our study suggests that ACE I/D polymorphism is associated with AF and the DD genotype may be an independent predictive factor for AF in patients with hypertensive heart disease.
|
19117407 |
2009 |
|
Atrial Fibrillation
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our study is to investigate whether treatment with ACE inhibitors (ACEIs) or angiotensin-receptor blockers (ARBs) could lower the risk of new AF in HCM.
|
29371376 |
2018 |
|
Atrial Fibrillation
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis suggests that there is insufficient evidence to demonstrate an association between ACE I/D polymorphism and AF risk.
|
21076147 |
2011 |
|
Atrial Fibrillation
|
0.400 |
Biomarker
|
disease |
CTD_human |
Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death.
|
15331425 |
2004 |
|
Atrial Fibrillation
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
It was recently suggested that the angiotensin-converting enzyme insertion/insertion genotype, which is considered to be protective against cardiovascular disease, was a significant risk factor for atrial fibrillation (AF) in patients with hypertrophic cardiomyopathy (HCM).
|
18037749 |
2007 |
|
Atrial Fibrillation
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Individuals with the ACE D/D genotype appear to be at higher risk of AF.
|
26041129 |
2015 |
|
Atrial Fibrillation
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In patients with CHF, the presence of AF was significantly associated with certain ACE and eNOS genotypes.
|
16818212 |
2006 |
|
Atrial Fibrillation
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In a study in a Japanese population, it was reported that the angiotensin-converting enzyme insertion/deletion polymorphism was not associated with atrial fibrillation.
|
14631130 |
2003 |
|
Atrial Fibrillation
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, the effects of angiotensin-converting-enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) on thrombogenicity in AF remain incompletely elucidated.
|
28980280 |
2018 |
|
Atrial Fibrillation
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic ACE I/D polymorphism and recurrence of atrial fibrillation after catheter ablation.
|
23876437 |
2013 |